Introduction: The management of huge intra-abdominal mass in pregnancy, a rare condition, involves careful evaluation and occasional surgical intervention. Low and middle-income countries are specifically faced with late and often-time, life-threatening presentations of this condition. The managing team should be equipped with the relevant clinical skills to care for this category of patients despite the limited resources at their disposal. Case report: We report a case of a 38-year-old primigravida who presented with a history of progressive abdominal swelling and weight loss of 6 years, as well as severe respiratory distress of 4 months. She had a background history of primary infertility […]

The understanding of how gene and the environment interact in controlling disease can now be expanded to include epigenetic reprogramming, which is a key determinant of origins of human disease and development. Epigenetics is defined as heritable changes in gene expression that do not alter DNA sequence but are mitotically and trans-generationally inheritable. Epigenetic reprogramming is the process by which an organism’s genotype interacts with the environment to produce its phenotype. This provides a framework for explaining individual variations and the uniqueness of cells, tissues, or organs despite identical genetic information. The main epigenetic mediators are DNA methylation, […]