Non-secretory Multiple Myeloma in a 37-year old pregnant woman in Owo: A Case Report
Keywords:
multiple myeloma, non-secretory, protein electrophoresisAbstract
Introduction: This is a report of non-secretory multiple myeloma in a young woman.
Case report: A 39-year old pregnant woman presented with chest pain, weight loss, generalized joint pain, body weakness, bilateral knee join swelling and fractures of the left humerus and distal femur. Investigations revealed leukocytosis, elevated plasma alkaline phosphatase, negative serum protein electrophoresis and Bence Jones protein, anaemia and elevated erythrocyte sedimentation rate. Skull X-ray showed moth-eaten appearance in keeping with myelomatosis. She had intrauterine foetal death; and was managed subsequently as a case of non-secretory multiple myeloma with chemotherapy and had a tremendous improvement.
Conclusion: This case illustrates the occurrence of patients with multiple myeloma who do not secrete immunoglobulins in our environment.
References
Corso A, Mangiacavalli S. Non-Secretory Myeloma: Ready for a new Definition? Mediterr J Hematol Infect Dis. 2017; 9(1):e2017053. doi: 10.4084/MJHID.2017.053.
Chawla SS, Kumar SK, Dispenzieri A, Greenberg AJ, Larson DR, Kyle RA, Lacy MQ, et al. Clinical course and prognosis of non-secretory multiple myeloma. Eur J Haematol. 2015; 95(1):57–64. https://doi.org/10.1111/ejh.12478.
Rajkumar SV. Multiple myeloma: Update on diagnosis, risk stratification and management. Am J. of Haematology 2022; 97(8):1086-1107.
Terpos E, Apperley JF, Samson D, Giles C, Crawley C, Kanfer E, et al. Autologous stem cell transplantation in multiple myeloma: improved survival in nonsecretory multiple myeloma but lack of influence of age, status at transplant, previous treatment and conditioning regimen. A single-centre experience in 127 patients. Bone Marrow Transplant. 2003; 31:163–70. https://doi.org/10.1038/sj.bmt.1703818.
Avet-Loiseau H, Garand R, Lodé L, Harousseau JL, Bataille R Intergroupe Francophone du Myélome. Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants. Blood. 2002; 101(4):1570–1571. https://doi.org/10.1182/blood-2002-08-2436.
Charliński G, Jurczyszyn A. Non-secretory multiple myeloma: Diagnosis and management. Adv Clin Exp Med. 2022; 31(1):95-100. doi: 10.17219/acem/141455.
Ferjani HL, Mariem M, Affess H, Maatallah K, Kaffel D, Jenri M, et al. Non-secretory multiple myeloma in a young man mimicking The Gorham’s disease: Case Report and Literature Review. Rom J Intern Med. 2022; 60(1):77-84.
Yadav RR, Singh A, Mathur SP,Mangal Y, Singh M. Non-secretory multiple myeloma presenting with diffused sclerosis of affected bones interspersed with osteolytic lesions. Br J. Radiol. 2009; 82(974):e29-31.
Neeravari A, Netravati P, Mohammed R, Ragupathi AR, Nagarajappa AH. Atypical imaging features of non-secretory multiple myeloma. Annal of Diagn Pathol; 2011; 268:72-79.
Nooka A, Langston A, Waller EK, Heffner LT, Gleason C, Muppidi S, et al. Early versus delayed autologous stem cell transplant (ASCT) in patients receiving induction therapy with lenalidomide, bortezomib, and dexamethasone (RVD) for newly diagnosed multiple myeloma (MM). J Clin Oncol. 2013; 31(15_suppl):8540. DOI: 10.1200/jco.2013.31.15_suppl.8540
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Western Nigeria Journal of Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
